Selected Publications

2017   2016    2015   2014    2013   2012    2011   2010    2009 & prior

Click to view Dr. Giguère's publications on Pubmed.




Inverse Regulation of DHT Synthesis Enzymes 5α-Reductase Types 1 and 2 by the Androgen Receptor in Prostate Cancer.

Audet-Walsh É, Yee T, Tam IS, Giguère V.  Endocrinology. 2017 Apr 1;158(4):1015-1021.


Androgen-Dependent Repression of ERRγ Reprograms Metabolism in Prostate Cancer.

Audet-Walsh É, Yee T, McGuirk S, Vernier M, Ouellet C, St-Pierre J, Giguère V.  Cancer Res. 2017 Jan 15;77(2):378-389.




Control of embryonic stem cell self-renewal and differentiation via coordinated alternative splicing and translation of YY2.

Tahmasebi S, Jafarnejad SM, Tam IS, Gonatopoulos-Pournatzis T, Matta-Camacho E, Tsukumo Y, Yanagiya A, Li W, Atlasi Y, Caron M, Braunschweig U, Pearl D, Khoutorsky A, Gkogkas CG, Nadon R, Bourque G, Yang XJ, Tian B, Stunnenberg HG, Yamanaka Y, Blencowe BJ, Giguère V, Sonenberg N.  Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):12360-12367.


ERRα mediates metabolic adaptations driving lapatinib resistance in breast cancer.

Deblois G, Smith HW, Tam IS, Gravel SP, Caron M, Savage P, Labbé DP, Bégin LR, Tremblay ML, Park M, Bourque G, St-Pierre J, Muller WJ, Giguère V.  Nat Commun. 2016 Jul 12;7:12156.


Chronic AMPK activation via loss of FLCN induces functional beige adipose tissue through PGC-1α/ERRα

Yan M, Audet-Walsh É, Manteghi S, Dufour CR, Walker B, Baba M, St-Pierre J, Giguère V, Pause A. Genes Dev. 2016 May 1;30(9):1034-46.


The PGC-1α/ERRα Axis Represses One-Carbon Metabolism and Promotes Sensitivity to Anti-folate Therapy in Breast Cancer.

Audet-Walsh É, Papadopoli DJ, Gravel SP, Yee T, Bridon G, Caron M, Bourque G, Giguère V, St-Pierre J. Cell Rep. 2016 Feb 2;14(4):920-31.


There and back again: The journey of the estrogen-related receptors in the cancer realm.

Tam IS, Giguère V. J Steroid Biochem Mol Biol. 2016 Mar;157:13-9.




Orphan Nuclear Receptor ERRα Controls Macrophage Metabolic Signaling and A20 Expression to Negatively Regulate TLR-Induced Inflammation.

Yuk JM, Kim TS, Kim SY, Lee HM, Han J, Dufour CR, Kim JK, Jin HS, Yang CS, Park KS, Lee CH, Kim JM, Kweon GR, Choi HS, Vanacker JM, Moore DD, Giguère V, Jo EK.  Immunity. 2015 Jul 21;43(1):80-91.


Estrogen-Related Receptor α (ERRα) and ERRγ Are Essential Coordinators of Cardiac Metabolism and Function.

Wang T, McDonald C, Petrenko NB, Leblanc M, Wang T, Giguère V, Evans RM, Patel VV, Pei L.  Mol Cell Biol. 2015 Apr 1;35(7):1281-98.


The multiple universes of estrogen-related receptor α and γ in metabolic control and related diseases.

Audet-Walsh É, Giguère V. Acta Pharmacol Sin. 2015 Jan;36(1):51-61.




Estrogen-related receptor-α coordinates transcriptional programs essential for exercise tolerance and muscle fitness.

Perry MC, Dufour CR, Tam IS, B'chir W, Giguère V. Mol Endocrinol. 2014 Dec;28(12):2060-71.


ERBB2 deficiency alters an E2F-1-dependent adaptive stress response and leads to cardiac dysfunction.

Perry MC, Dufour CR, Eichner LJ, Tsang DW, Deblois G, Muller WJ, Giguère V. Mol Cell Biol. 2014 Dec 1;34(23):4232-43.


Inactivation of RARβ inhibits Wnt1-induced mammary tumorigenesis by suppressing epithelial-mesenchymal transitions.

Liu X, Giguère V. Nucl Recept Signal. 2014 Nov 4;12:e004.


Estrogen-related receptor α decreases RHOA stability to induce orientated cell migration.

Sailland J, Tribollet V, Forcet C, Billon C, Barenton B, Carnesecchi J, Bachmann A, Gauthier KC, Yu S, Giguère V, Chan FL, Vanacker JM. Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):15108-13.


ELF3 is a repressor of androgen receptor action in prostate cancer cells.

Shatnawi A, Norris JD, Chaveroux C, Jasper JS, Sherk AB, McDonnell DP, Giguère V. Oncogene 2014 Feb 13;33(7):862-71.




PGC-1α supports glutamine metabolism in breast cancer.

McGuirk S, Gravel SP, Deblois G, Papadopoli DJ, Faubert B, Wegner A, Hiller K, Avizonis D, Akavia UD, Jones RG, Giguère V, St-Pierre J. Cancer Metab. 2013 Dec 5;1(1):22.


Loss of estrogen-related receptor α promotes hepatocarcinogenesis development via metabolic and inflammatory disturbances.

Hong EJ, Levasseur MP, Dufour CR, Perry MC, Giguère V. Proc Natl Acad Sci U S A. 2013 Oct 29;110(44):17975-80.


Molecular and genetic crosstalks between mTOR and ERRα are key determinants of rapamycin-induced nonalcoholic fatty liver.

Chaveroux C, Eichner LJ, Dufour CR, Shatnawi A, Khoutorsky A, Bourque G, Sonenberg N, Giguère V. Cell Metab. 2013 Apr 2;17(4):586-98.


Oestrogen-related receptors in breast cancer: control of cellular metabolism and beyond.

Deblois G, Giguère V. Nat Rev Cancer 2013 Jan;13(1):27-36.




PTP1B is an androgen receptor-regulated phosphatase that promotes the progression of prostate cancer.

Lessard L, Labbé DP, Deblois G, Bégin LR, Hardy S, Mes-Masson AM, Saad F, Trotman LC, Giguère V, Tremblay ML. Cancer Res. 2012 Mar 15;72(6):1529-37.


Cancer: Reprogramming clinical outcome.

Deblois G, Giguère V. Nature 2012 Jan 18;481(7381):275-6.




Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiation.

Michalek RD, Gerriets VA, Nichols AG, Inoue M, Kazmin D, Chang CY, Dwyer MA, Nelson ER, Pollizzi KN, Ilkayeva O, Giguère V, Zuercher WJ, Powell JD, Shinohara ML, McDonnell DP, Rathmell JC. Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18348-53.


Genomic convergence among ERRα, PROX1, and BMAL1 in the control of metabolic clock outputs.

Dufour CR, Levasseur MP, Pham NH, Eichner LJ, Wilson BJ, Charest-Marcotte A, Duguay D, Poirier-Héon JF, Cermakian N, Giguère V. PLoS Genet. 2011 Jun;7(6):e1002143.


Interferon regulatory factor 8 regulates pathways for antigen presentation in myeloid cells and during tuberculosis.

Marquis JF, Kapoustina O, Langlais D, Ruddy R, Dufour CR, Kim BH, MacMicking JD, Giguère V, Gros P. PLoS Genet. 2011 Jun;7(6):e1002097.


Stromal retinoic acid receptor beta promotes mammary gland tumorigenesis.

Liu X, Nugoli M, Laferrière J, Saleh SM, Rodrigue-Gervais IG, Saleh M, Park M, Hallett MT, Muller WJ, Giguère V. Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):774-9.




Transcriptional control of the ERBB2 amplicon by ERRalpha and PGC-1beta promotes mammary gland tumorigenesis.

Deblois G, Chahrour G, Perry MC, Sylvain-Drolet G, Muller WJ, Giguère V. Cancer Res. 2010 Dec 15;70(24):10277-87.


An acetylation switch modulates the transcriptional activity of estrogen-related receptor alpha.

Wilson BJ, Tremblay AM, Deblois G, Sylvain-Drolet G, Giguère V. Mol Endocrinol. 2010 Jul;24(7):1349-58.


The homeobox protein Prox1 is a negative modulator of ERR{alpha}/PGC-1{alpha} bioenergetic functions.

Charest-Marcotte A, Dufour CR, Wilson BJ, Tremblay AM, Eichner LJ, Arlow DH, Mootha VK, Giguère V. Cancer Res. 2010 Mar 15;24(6):537-42.


2009 & prior


Phosphatases at the heart of FoxO metabolic control.

Tremblay ML, Giguère V. Cell Metab. 2008 Feb;7(2):101-3.


ERRgamma directs and maintains the transition to oxidative metabolism in the postnatal heart.

Alaynick WA, Kondo RP, Xie W, He W, Dufour CR, Downes M, Jonker JW, Giles W, Naviaux RK, Giguère V, Evans RM. Cell Metab. 2007 Jul;6(1):13-24.


Genome-wide orchestration of cardiac functions by the orphan nuclear receptors ERRalpha and gamma.

Dufour CR, Wilson BJ, Huss JM, Kelly DP, Alaynick WA, Downes M, Evans RM, Blanchette M, Giguère V. Cell Metab. 2007 May;5(5):345-56.


Location analysis of estrogen receptor alpha target promoters reveals that FOXA1 defines a domain of the estrogen response.

Laganière J, Deblois G, Lefebvre C, Bataille AR, Robert F, Giguère V. Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11651-6.


Epidermal growth factor-induced signaling in breast cancer cells results in selective target gene activation by orphan nuclear receptor estrogen-related receptor alpha.

Barry JB, Giguère V. Cancer Res. 2005 Jul 15;65(14):6120-9.


Transcriptional regulation of the estrogen-inducible pS2 breast cancer marker gene by the ERR family of orphan nuclear receptors.

Lu D, Kiriyama Y, Lee KY, Giguère V. Cancer Res. 2001 Sep 15;61(18):6755-61.