The Giguère lab studies the roles played by nuclear receptors in development, physiology and diseases, especially hormone-dependent cancers. Nuclear receptors are transcription factors that regulate the expression of vast gene networks in response to a variety of hormones, vitamins, lipids and synthetic drugs. We use state-of-the-art technologies such as functional genomics and metabolomics to explore the molecular mechanisms by which nuclear receptors control gene expression and influence cellular function. The group is well funded, has led several rewarding research projects and trained numerous graduate students and post-doctoral fellows who have successfully obtained independent positions in academia, industry, government and the health care field.
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